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oYo-Link
oYo-Link® Antibody Labeling
Simple, fast, site-Specific antibody labeling with only 30 seconds hands-on time
- 2 steps, mix & illuminate
- 30 seconds hands-on time, 2 hours total conjugation time
- Compatible with all common buffers. 90% labeling efficiency of most antibodies
- Label as little as 1 µg of antibody per reaction
Trusted by Scientists Worldwide
oYo-Link® Oligo
Spatial profiling of human pancreatic ductal adenocarcinoma reveals molecular alterations associated with venous invasion
Science Translational Medicine (2025)
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oYo-Link® Oligo
Deep-tissue transcriptomics and subcellular imaging at high spatial resolution
Science (2025)
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oYo-Link® Oligo
Cassini: Streamlined and Scalable Method for in situ profiling of RNA and Protein
Nature Communications (2025)
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oYo-Link® Oligo
A method for Boolean analysis of protein interactions at a molecular level
Nature Communications (2022)
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oYo-Link® Oligo
Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging
Cell (2024)
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oYo-Link® Oligo
Efficient DNA fluorescence labeling via base excision trapping
Nature Communications (2022)
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oYo-Link® DBCO
Multiplexed In Situ Imaging of Site-Specific m6A Methylation with Proximity Hybridization Followed by Primer Exchange Amplification
ACS (2024)
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oYo-Link® Oligo
DNA-based AND logic gate as a molecular precision tool: selective recognition of protein pairs in lipid nanodiscs and subsequent binding of gold nanorods
PrePrint: ChemRvix
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oYo-Link® Epitope Tag
Epitope Tag Conjugation system provides versatility for multiples assay design
The Journal of Immunology (2023)
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oYo-Link® Oligo
Agarose Microgel-Based In Situ Cleavable Immuno-Rolling Circle Amplification for Multiplexed Single-Molecule Quantitation on Single Extracellular Vesicles
ACS
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oYo-Link® Tetrazine
Peptide sequencing via reverse translation of peptides into DNA
PrePrint: BioRvix
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oYo-Link® Oligo
Fixation Before Dissociation Using a Deep Eutectic Solvent Preserves In Vivo States and Phospho-Signaling in Single-Cell Sequencing
PrePrint: BioRvix
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oYo-Link® Azide
Harnessing synaptic vesicle release and recycling with antibody shuttle for targeted delivery of therapeutics to neurons
Molecular Therapy
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oYo-Link® Oligo
Non-disruptive 3D profiling of combinations of epigenetic marks in single cells
PrePrint: BioRvix
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oYo-Link® Oligo
Integration of phospho-signaling and transcriptomics in single cells reveals distinct Th17 cell fates
Cell
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oYo-Link® Oligo
DNA-Directed Assembly of Multivalent Lipid Nanoparticles for Targeted T Cell Gene Delivery
PrePrint: BioRvix
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Our Products & Services
New Products!
oYo-Link® SureLight®
Fluorescent Protein Labeling
Rapid, covalent, site-specific labeling of primary antibodies with fluorescent proteins in just 2 steps – mix and illuminate. Highly homogenous conjugates with no need to optimize labeling conditions.
oYo-Link® Oligo Custom
Site-specific antibody-oligo conjugation in under 2 hours, with only 30s hands-on time. Label custom ss & ds oligos up to 80bp or longer.
oYo-Link® ADC Reagents
For rapid, site-specific labeling of antibodies with up to two drug labels per antibody. No need for purification post conjugation, proceed directly to the cell killing assay.
The oYo-Link® Technology
Simple, fast, site-specific antibody labeling
How it works
oYo-Link® reagents consist of low molecular weight (~8 kDa), high-affinity antibody-binding domains that possess a photo-crosslinker within their Fc-binding site. Upon illumination with non-damaging Black-light, oYo-Link forms a covalent bond with the antibody.
Site Specific Antibody Labeling
Uniform labeling of up to 2 labels per Antibody on the heavy chain resulting in improved antibody performance, highly uniform product, and consistent, predictable results.
News
View more newsRelocation Marks Next Step in AlphaThera’s Expansion
AlphaThera today announced its relocation to a significantly larger laboratory and office facility at 3675 Market Street in the heart of Philadelphia’s University City, marking an important milestone in the company’s growth. The move will provide the company with twice the space of their existing location, combining both laboratory and office space to allow for […]
Columbia Biosciences and AlphaThera partner to develop range of Site-Specific Fluorescent Protein Labeling Reagents
The partnership will provide the life science market with an innovative conjugation chemistry for antibody labeling.
AlphaThera relocates to accommodate the company’s rapid expansion
AlphaThera have announced their relocation to a new larger laboratory and office space within the Pennovation Works Lab Building at the University of Pennsylvania.
Our Blog
Simple. Fast. Site-Specific antibody labeling.